Article
Apolipoprotein E2(Arg158----Cys) frequency in a hyperlipidemic French-Canadian population of apolipoprotein E2/2 subjects. Determination by synthetic oligonucleotide probes.
Arteriosclerosis (Dallas, Tex.) - 1 Jan 2000
Weisgraber K H, Newhouse Y M, Taylor J M, Tuan B, Nestruck A C, Davignon J, Mahley R W
Abstract excerpt
An underlying cause of type III hyperlipoproteinemia is the presence of variant forms of apolipoprotein (apo) E that are defective in binding to apo B,E low density lipoprotein receptors. This disorder is associated almost exclusively with the apo E2/2 phenotype. However, structural and functional heterogeneity have been demonstrated within this phenotype. The apo E2(Arg158----Cys) variant, displaying 1% of...
Topics
- Adult
- Aged
- Amino Acid Sequence
- Apolipoprotein E2
- Apolipoproteins E
- Arginine
- Base Sequence
- Cysteine
- DNA
- Female
- Gene Frequency