Article
Salt bridge relay triggers defective LDL receptor binding by a mutant apolipoprotein.
Structure (London, England : 1993) - 15 Aug 1994
Wilson C, Mau T, Weisgraber K H, Wardell M R, Mahley R W, Agard D A
Abstract excerpt
BACKGROUND: Apolipoprotein-E (apo-E), a 34kDa blood plasma protein, plays a key role in directing cholesterol transport via its interaction with the low density lipoprotein (LDL) receptor. The amino-terminal domain of apo-E forms an unusually elongated four-helix bundle arranged such that key bas...
Topics
- Apolipoprotein E2
- Apolipoproteins E
- Computer Simulation
- Crystallography
- Humans
- Models, Molecular
- Mutation
- Peptide Fragments
- Protein Conformation
- Receptors, LDL