Article
Production of a high-efficiency TILLING population through polyploidization.
Plant physiology - 1 Apr 2013
Tsai Helen, Missirian Victor, Ngo Kathie J, Tran Robert K, Chan Simon R, Sundaresan Venkatesan, Comai Luca
Abstract excerpt
Targeting Induced Local Lesions in Genomes (TILLING) provides a nontransgenic method for reverse genetics that is widely applicable, even in species where other functional resources are missing or expensive to build. The efficiency of TILLING, however, is greatly facilitated by high mutation density. Species vary in the number of mutations induced by comparable mutagenic treatments, suggesting that genetic...
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