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Folic acid intervention during pregnancy alters DNA methylation, affecting neural target genes through two distinct mechanisms

16 May 2022

Abstract excerpt

BACKGROUND: We previously showed that continued folic acid (FA) supplementation beyond the first trimester of pregnancy appears to have beneficial effects on neurocognitive performance in children followed for up to 11 years, but the biological mechanism for this effect has remained unclear. Using samples from our randomized controlled trial of folic acid supplementation in second and third trimester (FASSTT),...

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PMID: 35578268
DOI: 10.1186/s13148-022-01282-y

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