Article
A genotype-controlled analysis of plasma dopamine beta-hydroxylase in healthy and alcoholic subjects: evidence for alcohol-related differences in noradrenergic function.
Biological psychiatry - 15 Dec 2002
Köhnke Michael D, Zabetian Cyrus P, Anderson George M, Kolb Werner, Gaertner Ines, Buchkremer Gerhard, Vonthein Reinhard, Schick Sandra, Lutz Ulrich, Köhnke Annette M, Cubells Joseph F
Abstract excerpt
BACKGROUND: Norepinephrine and dopamine mediate important aspects of alcoholism and alcohol withdrawal. Dopamine-beta-hydroxylase (DbetaH) converts dopamine to norepinephrine. A recent study demonstrated a strong association between variance in plasma DbetaH activity and a novel polymorphism (DBH-1021C-->T) at the structural locus (DBH) encoding DbetaH protein. METHODS: Our study investigated whether the...
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