Article
The dopamine β-hydroxylase -1021C/T polymorphism is associated with the risk of Alzheimer's disease in the Epistasis Project.
BMC medical genetics - 11 Nov 2010
Combarros Onofre, Warden Donald R, Hammond Naomi, Cortina-Borja Mario, Belbin Olivia, Lehmann Michael G, Wilcock Gordon K, Brown Kristelle, Kehoe Patrick G, Barber Rachel, Coto Eliecer, Alvarez Victoria, Deloukas Panos, Gwilliam Rhian, Heun Reinhard, Kölsch Heike, Mateo Ignacio, Oulhaj Abderrahim, Arias-Vásquez Alejandro, Schuur Maaike, Aulchenko Yurii S, Ikram M Arfan, Breteler Monique M, van Duijn Cornelia M, Morgan Kevin, Smith A David, Lehmann Donald J
Abstract excerpt
BACKGROUND: The loss of noradrenergic neurones of the locus coeruleus is a major feature of Alzheimer's disease (AD). Dopamine β-hydroxylase (DBH) catalyses the conversion of dopamine to noradrenaline. Interactions have been reported between the low-activity -1021T allele (rs1611115) of DBH and polymorphisms of the pro-inflammatory cytokine genes, IL1A and IL6, contributing to the risk of AD. We therefore...
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