Article
A quantitative-trait analysis of human plasma-dopamine beta-hydroxylase activity: evidence for a major functional polymorphism at the DBH locus.
American journal of human genetics - 1 Feb 2001
Zabetian C P, Anderson G M, Buxbaum S G, Elston R C, Ichinose H, Nagatsu T, Kim K S, Kim C H, Malison R T, Gelernter J, Cubells J F
Abstract excerpt
Dopamine-beta-hydroxylase (D beta H) catalyzes the conversion of dopamine to norepinephrine and is released from sympathetic neurons into the circulation. Plasma-D beta H activity varies widely between individuals, and a subgroup of the population has very low activity levels. Mounting evidence suggests that the DBH structural gene is itself the major quantitative-trait locus (QTL) for plasma-D beta H activity,...
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