Age-dependent association between pulmonary tuberculosis and common TOX variants in the 8q12-13 linkage region.

doi:10.1016/j.ajhg.2013.01.013

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Article

Age-dependent association between pulmonary tuberculosis and common TOX variants in the 8q12-13 linkage region.

American journal of human genetics - 7 Mar 2013

Grant Audrey V, El Baghdadi Jamila, Sabri Ayoub, El Azbaoui Safa, Alaoui-Tahiri Kebir, Abderrahmani Rhorfi Ismail, Gharbaoui Yasser, Abid Ahmed, Benkirane Majid, Raharimanga Vaomalala, Richard Vincent, Orlova Marianna, Boland Anne, Migaud Mélanie, Okada Satoshi, Nolan Daniel K, Bustamante Jacinta, Barreiro Luis B, Schurr Erwin, Boisson-Dupuis Stephanie, Rasolofo Voahangy, Casanova Jean-Laurent, Abel Laurent

Abstract excerpt

Only a small fraction of individuals infected with Mycobacterium tuberculosis develop clinical tuberculosis (TB) in their lifetime. Genetic epidemiological evidence suggests a genetic determinism of pulmonary TB (PTB), but the molecular basis of genetic predisposition to PTB remains largely unknown. We used a positional-cloning approach to carry out ultrafine linkage-disequilibrium mapping of a previously...

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PMID: 23415668
DOI: 10.1016/j.ajhg.2013.01.013
PMCID: PMC3591857

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