Article
Association of PTPN22 gene functional variants with development of pulmonary tuberculosis in Moroccan population.
Tissue antigens - 1 Sept 2009
Lamsyah H, Rueda B, Baassi L, Elaouad R, Bottini N, Sadki K, Martin J
Abstract excerpt
Mycobacterium tuberculosis, the causal agent of pulmonary tuberculosis (TB), remains a major health problem throughout the world causing high mortality in humans. Previous studies showed that several genes may play crucial roles in susceptibility to TB. The PTPN22 gene encodes the lymphoid tyrosine phosphatase that has an important regulatory effect on T- and B-cell activation in immune response. The purpose of...
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