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Article

Gene expression deficits in pontine locus coeruleus astrocytes in men with major depressive disorder.

Journal of psychiatry & neuroscience : JPN - 1 Jul 2013

Chandley Michelle J, Szebeni Katalin, Szebeni Attila, Crawford Jessica, Stockmeier Craig A, Turecki Gustavo, Miguel-Hidalgo Jose Javier, Ordway Gregory A

Abstract excerpt

BACKGROUND: Norepinephrine and glutamate are among several neurotransmitters implicated in the neuropathology of major depressive disorder (MDD). Glia deficits have also been demonstrated in people with MDD, and glia are critical modulators of central glutamatergic transmission. We studied glia in men with MDD in the region of the brain (locus coeruleus; LC) where noradrenergic neuronal cell bodies reside and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23415275
DOI: 10.1503/jpn.120110
PMCID: PMC3692725

Genes

GFAP
GLUL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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