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Article

Merlin Knockdown in Human Schwann Cells

18 Mar 2010

Abstract excerpt

HYPOTHESIS: To investigate the early events in molecular progression toward schwannoma tumorigenesis, we developed an in vitro model of human Schwann cell tumorigenesis by merlin knockdown. BACKGROUND: Neurofibromatosis 2 (NF2)-related and sporadic vestibular schwannoma (VS) exhibit loss of functional merlin (schwannomin). After loss of merlin expression in the Schwann cell, the initial steps toward VS...

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PMID: 20195187
DOI: 10.1097/mao.0b013e3181d2777f

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