Article
Genetic regulation of host resistance to bacterial infection.
Reviews of infectious diseases - 1 Jan 2000
Skamene E
Abstract excerpt
Genetic analysis of host resistance to microbes represents a valuable tool for studies of the pathogenesis of infection. Marked intraspecies differences in resistance or susceptibility among inbred mice are invariably the result of a particular genetic makeup of the host. Appropriate breeding experiments can be designed for the study of the mode of inheritance and of the chromosomal location of the resistance...
Topics
- Animals
- Bacterial Infections
- Chromosome Mapping
- Genes
- Humans
- Immunity, Innate
- Mice
- Mice, Inbred Strains
- Phenotype
- Species Specificity
