Article
M tuberculosis in the adjuvant modulates time of appearance of CNS-specific effector T cells in the spleen through a polymorphic site of TLR2.
PloS one - 1 Jan 2013
Nicolò Chiara, Di Sante Gabriele, Procoli Annabella, Migliara Giuseppe, Piermattei Alessia, Valentini Mariagrazia, Delogu Giovanni, Cittadini Achille, Constantin Gabriela, Ria Francesco
Abstract excerpt
DC deliver information regulating trafficking of effector T cells along T-cell priming. However, the role of pathogen-derived motives in the regulation of movement of T cells has not been studied. We hereinafter report that amount of M tuberculosis in the adjuvant modulates relocation of PLP139-151 specific T cells. In the presence of a low dose of M tuberculosis in the adjuvant, T cells (detected by CDR3 BV-BJ...
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