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Article

Candidate sequence variants and fetal hemoglobin in children with sickle cell disease treated with hydroxyurea.

PloS one - 1 Jan 2013

Green Nancy S, Ender Katherine L, Pashankar Farzana, Driscoll Catherine, Giardina Patricia J, Mullen Craig A, Clark Lorraine N, Manwani Deepa, Crotty Jennifer, Kisselev Sergey, Neville Kathleen A, Hoppe Carolyn, Barral Sandra

Abstract excerpt

BACKGROUND: Fetal hemoglobin level is a heritable complex trait that strongly correlates swith the clinical severity of sickle cell disease. Only few genetic loci have been identified as robustly associated with fetal hemoglobin in patients with sickle cell disease, primarily adults. The sole approved pharmacologic therapy for this disease is hydroxyurea, with effects largely attributable to induction of fetal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23409025
DOI: 10.1371/journal.pone.0055709
PMCID: PMC3567082

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HBB

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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