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Article

Fetal hemoglobin in sickle cell anemia: genetic determinants of response to hydroxyurea.

The pharmacogenomics journal - 1 Dec 2007

Ma Q, Wyszynski D F, Farrell J J, Kutlar A, Farrer L A, Baldwin C T, Steinberg M H

Abstract excerpt

The increase in fetal hemoglobin (HbF) in response to hydroxyurea (HU) varies among patients with sickle cell anemia. Twenty-nine candidate genes within loci previously reported to be linked to HbF level (6q22.3-q23.2, 8q11-q12 and Xp22.2-p22.3), involved in metabolism of HU and related to erythroid progenitor proliferation were studied in 137 sickle cell anemia patients treated with HU. Three-hundred and twenty...

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Source

Identifiers

PMID: 17299377
DOI: 10.1038/sj.tpj.6500433

Genes

ARG2
FLT1
HAO2
NOS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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