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Article

Prediction of fetal hemoglobin in sickle cell anemia using an ensemble of genetic risk prediction models.

Circulation. Cardiovascular genetics - 1 Apr 2014

Milton Jacqueline N, Gordeuk Victor R, Taylor James G, Gladwin Mark T, Steinberg Martin H, Sebastiani Paola

Abstract excerpt

BACKGROUND: Fetal hemoglobin (HbF) is the major modifier of the clinical course of sickle cell anemia. Its levels are highly heritable, and its interpersonal variability is modulated in part by 3 quantitative trait loci that affect HbF gene expression. Genome-wide association studies have identified single-nucleotide polymorphisms (SNPs) in these quantitative trait loci that are highly associated with HbF but...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24585758
DOI: 10.1161/CIRCGENETICS.113.000387
PMCID: PMC3994553

Genes

HBB
MYB

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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