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Article

Glucocorticoid receptor Gene (NR3C1) Polymorphisms and Haplotypes in patients with congenital adrenal hyperplasia.

Molecular and cellular endocrinology - 1 Oct 2021

Villela Thais Ramos, Barra Cristina Botelho, Belisário André Rolim, Luizon Marcelo Rizzatti, Simões E Silva Ana Cristina, Silva Ivani Novato

Abstract excerpt

BACKGROUND: Lifelong glucocorticoid (GC) replacement is the mainstay treatment of congenital adrenal hyperplasia (CAH) due to classic 21-hydroxylase deficiency (21-OHD). Challenges posed by therapeutic management of these patients are well known, but novel insights into the variability in clinical response to GC highlight a role for single nucleotide polymorphisms (SNPs) of the glucocorticoid receptor gene...

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Share to Adrenal Hyperplasia, Congenital
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34298075
DOI: 10.1016/j.mce.2021.111399

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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