Article
An association analysis of HLA-DRB1 with systemic lupus erythematosus and rheumatoid arthritis in a Japanese population: effects of *09:01 allele on disease phenotypes.
Rheumatology (Oxford, England) - 1 Jul 2013
Shimane Kenichi, Kochi Yuta, Suzuki Akari, Okada Yukinori, Ishii Tomonori, Horita Tetsuya, Saito Kazuyoshi, Okamoto Akiko, Nishimoto Norihiro, Myouzen Keiko, Kubo Michiaki, Hirakata Michito, Sumida Takayuki, Takasaki Yoshinari, Yamada Ryo, Nakamura Yusuke, Kamatani Naoyuki, Yamamoto Kazuhiko
Abstract excerpt
Objective. To re-evaluate the roles of HLA-DRB1 alleles in susceptibility to SLE and RA and their effects on autoantibody status in large-scale Japanese cohorts. Methods. A total of 656 SLE, 2410 RA and 911 control subjects, who were all Japanese, were genotyped for HLA-DRB1 alleles using sequence-specific oligonucleotide probes. The association of alleles with disease susceptibility was tested by logistic...
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