Article
Relevance of autoantibody profile with HLA-DRB1 and -DQB1 alleles in a group of Iranian systemic lupus erythematosus patients.
Immunology letters - 1 Sept 2021
Rasouli-Saravani Ashkan, Tahamoli-Roudsari Ahmad, Basiri Zahra, Babaei Mahboobeh, Fazaeli Alireza, Roshanaei Ghodratollah, Hajilooi Mehrdad, Solgi Ghasem
Abstract excerpt
BACKGROUND: One of the most relevant genetic components in systemic lupus erythematosus (SLE) is human leukocyte antigen (HLA) gene complex which plays a central role in autoimmune responses. This study aimed to explore the associations of HLA-DRB1/-DQB1 alleles and haplotypes with SLE risk and the appearance of autoantibodies in SLE disease. METHODS: A total of 127 SLE patients and 153 ethnically matched healthy...
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