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Article

Myod and H19-Igf2 locus interactions are required for diaphragm formation in the mouse

14 Feb 2013

Abstract excerpt

The myogenic regulatory factor Myod and insulin-like growth factor 2 (Igf2) have been shown to interact in vitro during myogenic differentiation. In order to understand how they interact in vivo, we produced double-mutant mice lacking both the Myod and Igf2 genes. Surprisingly, these mice display neonatal lethality due to severe diaphragm atrophy. Alteration of diaphragm muscle development occurs as early as 15.5...

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PMID: 23406902
DOI: 10.1242/dev.084665

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