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Article

H19 lncRNA controls gene expression of the Imprinted Gene Network by recruiting MBD1.

Proceedings of the National Academy of Sciences of the United States of America - 17 Dec 2013

Monnier Paul, Martinet Clémence, Pontis Julien, Stancheva Irina, Ait-Si-Ali Slimane, Dandolo Luisa

Abstract excerpt

The H19 gene controls the expression of several genes within the Imprinted Gene Network (IGN), involved in growth control of the embryo. However, the underlying mechanisms of this control remain elusive. Here, we identified the methyl-CpG-binding domain protein 1 MBD1 as a physical and functional partner of the H19 long noncoding RNA (lncRNA). The H19 lncRNA-MBD1 complex is required for the control of five genes...

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Topics

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Share to DNA Methylation
Share to Embryo, Mammalian

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Developmental

Share to Gene Regulatory Networks

Share to Genomic Imprinting

Share to Mice, Knockout

Share to Ribonucleoproteins

Share to RNA, Long Noncoding

Source

Open in PubMed Open full text

Identifiers

PMID: 24297921
DOI: 10.1073/pnas.1310201110
PMCID: PMC3870736

Genes

MBD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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