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Mouse primordial germ cells produce cysts that partially fragment prior to meiosis

12 Apr 2013

Abstract excerpt

Mammalian germ cells divide mitotically and form nests of associated cells just prior to entering meiosis. At least some nests contain germline cysts that arise by synchronous, incomplete mitotic divisions, but others may form by aggregation. To systematically investigate early murine germ cell development, we lineage marked the progeny of individual, newly arrived primordial germ cells in the E10.5 gonad. All...

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PMID: 23578925
DOI: 10.1242/dev.093864

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