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Article

Effects of antidepressant treatment on mice lacking brain-derived neurotrophic factor expression through promoter IV.

The European journal of neuroscience - 1 Jun 2013

Sakata Kazuko, Mastin Joshua R, Duke Sean M, Vail Meghan G, Overacre Abigail E, Dong Brittany E, Jha Shanker

Abstract excerpt

Brain-derived neurotrophic factor (BDNF) is implicated in the pathophysiology of major depression; mice lacking BDNF expression through promoter IV (BDNF-KIV) exhibit a depression-like phenotype. We tested our hypothesis that deficits caused by promoter IV deficiency (depression-like behavior, decreased levels of BDNF, and neurogenesis in the hippocampus) could be rescued by a 3-week treatment with different...

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Identifiers

PMID: 23406189
DOI: 10.1111/ejn.12148

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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