Article
Increased neurogenesis and brain-derived neurotrophic factor in neurokinin-1 receptor gene knockout mice.
The European journal of neuroscience - 1 Oct 2003
Morcuende Sara, Gadd Christopher A, Peters Marco, Moss Andrew, Harris Elizabeth A, Sheasby Anne, Fisher Amy S, De Felipe Carmen, Mantyh Patrick W, Rupniak Nadia M J, Giese K Peter, Hunt Stephen P
Abstract excerpt
It has previously been shown that chronic treatment with antidepressant drugs increases neurogenesis and levels of brain-derived neurotrophic factor in the hippocampus. These changes have been correlated with changes in learning and long-term potentiation and may contribute to the therapeutic efficacy of antidepressant drug treatment. Recently, antagonists at the neurokinin-1 receptor, the preferred receptor for...
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