Article
Molecular characterization of HAMP rs10421768 gene and phenotypic expression of hepcidin; a case-control study among sickle cell anaemia patients in Ghana.
PloS one - 1 Jan 2024
Appiah Samuel Kwasi, Nkansah Charles, Abbam Gabriel, Osei-Boakye Felix, Mensah Kofi, Bani Simon Bannison, Chemogo Solomon, Sarpong Lydia, Addae Takyi Godfred, Sefa Daniel Boamah, Croffien Richard Adu, Adom Larry, Rauf Rekhiatu Oboirien Abdul, Boadu Farrid, Amoah Godfred Appiah, Chukwurah Ejike Felix
Abstract excerpt
BACKGROUND: The sporadic nature of blood transfusion therapy coupled with the alteration of HAMP genes may exacerbate the risk of iron burden in sickle cell anaemia (SCA) patients. The study determined the polymorphic distribution of the HAMP promoter gene rs10421768 and hepcidin levels in SCA patients. METHOD: Sixty participants aged ≥12years [45 SCA patients and 15 controls (HbA)] were recruited from 15th...
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