Article
Association of G6PD with lower haemoglobin concentration but not increased haemolysis in patients with sickle cell anaemia.
British journal of haematology - 1 Jul 2010
Nouraie Mehdi, Reading Noel S, Campbell Andrew, Minniti Caterina P, Rana Sohail R, Luchtman-Jones Lori, Kato Gregory J, Gladwin Mark T, Castro Oswaldo L, Prchal Josef T, Gordeuk Victor R
Abstract excerpt
The genetic bases of the highly variable degrees of anaemia and haemolysis in persons with Hb SS are not fully known, but several studies have indicated that G6PD deficiency is not a factor. The G6PD(202A) and G6PD(376G) alleles and alpha-thalassaemia were determined by molecular genetic testing in 261 children and adolescents with Hb SS in a multicentre study. G6PD(202A,376G) (G6PD A-) was defined as...
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