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Article

Clinics and genetics of hyperhemolysis syndrome in patients with sickle cell disease.

Transfusion - 1 May 2025

Malta Barbara, Cintho Ozahata Mina, Gomes Moura Isabel Cristina, Amorim Luiz, Ferraz Alessandra, Belisário André Rolim, Miranda Carolina, Kelly Shannon, Custer Brian, Sabino Ester C, Dinardo Carla L

Abstract excerpt

BACKGROUND: Hyperhemolysis syndrome (HHS) is a severe transfusion-related complication with a complex immune pathophysiology, primarily affecting individuals with sickle cell disease (SCD). Limited research has investigated the clinical and molecular risk factors for HHS, which could help identify at-risk patients. This study aimed to assess clinical factors associated with HHS and identify genetic variations...

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Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40172242
DOI: 10.1111/trf.18232
PMCID: PMC12088895

Genes

PHRF1
SCD
STAT5B
BLNK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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