Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Leishmania donovani methionine adenosyltransferase. Role of cysteine residues in the recombinant enzyme.

European journal of biochemistry - 1 Jan 2003

Pérez-Pertejo Yolanda, Reguera Rosa M, Villa Hector, García-Estrada Carlos, Balaña-Fouce Rafael, Pajares Maria A, Ordóñez David

Abstract excerpt

Methionine adenosyltransferase (MAT, EC 2.5.1.6)-mediated synthesis of S-adenosylmethionine (AdoMet) is a two-step process consisting of the formation of AdoMet and the subsequent cleavage of the tripolyphosphate (PPPi) molecule, a reaction induced, in turn, by AdoMet. The fact that the two activities, AdoMet synthesis and tripolyphosphate hydrolysis, can be measured separately is particularly useful when the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cysteine
Share to Feedback, Physiological

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hydrolysis

Share to Leishmania donovani

Share to Methionine Adenosyltransferase

Share to Polyphosphates

Share to Protein Folding

Share to S-Adenosylmethionine

Source

Identifiers

PMID: 12492472
DOI: 10.1046/j.1432-1033.2003.03355.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Leishmania donovani methionine adenosyltransferase. Role of cysteine residues in the recombinant enzyme.PMID 12492472Read ↗

S-adenosylmethionine decarboxylase from Leishmania donovani. Molecular, genetic, and biochemical characterization of null mutants and overproducers.Semantic proximity Read ↗

Genetic Manipulation of Leishmania donovani to Explore the Involvement of Argininosuccinate Synthase in Oxidative Stress Management.Semantic proximity Read ↗

Biochemical and genetic analysis of methylenetetrahydrofolate reductase in Leishmania metabolism and virulence.Semantic proximity Read ↗

The bifunctional active site of s-adenosylmethionine synthetase. Roles of the active site aspartates.Semantic proximity Read ↗

Adenylosuccinate synthetase and adenylosuccinate lyase deficiencies trigger growth and infectivity deficits in Leishmania donovani.Semantic proximity Read ↗

Mutations of key substrate binding residues of leishmanial peptidase T alter its functional and structural dynamics.Semantic proximity Read ↗

Functional analysis of an AMP forming acetyl CoA synthetase from Leishmania donovani by gene overexpression and targeted gene disruption approaches.Semantic proximity Read ↗

The role of the mitochondrial glycine cleavage complex in the metabolism and virulence of the protozoan parasite Leishmania major.Semantic proximity Read ↗

Xanthine phosphoribosyltransferase from Leishmania donovani. Molecular cloning, biochemical characterization, and genetic analysis.Semantic proximity Read ↗

Cloning and Characterization of a Leucyl Aminopeptidase from Three Pathogenic Leishmania SpeciesSemantic proximity Read ↗

Expression and alteration of the S2 subsite of the Leishmania major cathepsin B-like cysteine protease.Semantic proximity Read ↗

Kinetic characterization of methionine gamma-lyases from the enteric protozoan parasite Entamoeba histolytica against physiological substrates and trifluoromethionine, a promising lead compound against amoebiasis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.