Article
BRAF(V600E) protein expression and outcome from BRAF inhibitor treatment in BRAF(V600E) metastatic melanoma.
British journal of cancer - 5 Mar 2013
Wilmott J S, Menzies A M, Haydu L E, Capper D, Preusser M, Zhang Y E, Thompson J F, Kefford R F, von Deimling A, Scolyer R A, Long G V
Abstract excerpt
BACKGROUND: To examine the association between level and patterns of baseline intra-tumoural BRAF(V600E) protein expression and clinical outcome of BRAF(V600E) melanoma patients treated with selective BRAF inhibitors. METHODS: Fifty-eight BRAF(V600E) metastatic melanoma patients treated with dabrafenib or vemurafenib on clinical trials had pre-treatment tumour BRAF(V600E) protein expression immunohistochemically...
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