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Pharmacogenetics and clinical biomarkers for subtherapeutic plasma efavirenz concentration in HIV-1 infected Thai adults.

Drug metabolism and pharmacokinetics - 1 Jan 2014

Sukasem Chonlaphat, Chamnanphon Montri, Koomdee Napatrupron, Santon Siwalee, Jantararoungtong Thawinee, Prommas Santirat, Puangpetch Apichaya, Manosuthi Weerawat

Abstract excerpt

The aim of this study was to assess the influence of host genetic variations and clinical factors in relation to efavirenz level in HIV-1 infected Thai adults. A total of 100 HIV-infected subjects treated with efavirenz/lamivudine/tenofivir were prospectively enrolled. The panel of CYP2A6, CYP2B6 and CYP3A4/5 polymorphisms was genotyped. At steady state, plasma efavirenz concentrations were measured using high...

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PMID: 24477223
DOI: 10.2133/dmpk.dmpk-13-rg-077

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