Low level of efavirenz in HIV-1-infected Thai adults is associated with the CYP2B6 polymorphism.

doi:10.1007/s15010-013-0560-6

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Article

Low level of efavirenz in HIV-1-infected Thai adults is associated with the CYP2B6 polymorphism.

Infection - 1 Jun 2014

Sukasem C, Manosuthi W, Koomdee N, Santon S, Jantararoungtong T, Prommas S, Chamnanphol M, Puangpetch A, Sungkanuparph S

Abstract excerpt

BACKGROUND: Human immunodeficiency virus type 1 (HIV-1) infections with a plasma efavirenz concentration of <1,000 ng/mL appear to have a high risk for the emergence of drug resistance. In the present study, we assessed the influence of the CYP2B6 polymorphism on the plasma efavirenz level. METHODS: CYP2B6 T18492C (rs2279345) in 149 HIV-infected Thai adults were genotyped. Plasma efavirenz concentrations 12 h...

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PMID: 24293076
DOI: 10.1007/s15010-013-0560-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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