Article
Decreased mortality associated with statin treatment in patients with acute myocardial infarction and lymphotoxin-alpha C804A polymorphism.
Atherosclerosis - 1 Apr 2013
Suna Shinichiro, Sakata Yasuhiko, Nakatani Daisaku, Okuda Keiji, Shimizu Masahiko, Usami Masaya, Matsumoto Sen, Hara Masahiko, Ozaki Kouichi, Mizuno Hiroya, Minamino Tetsuo, Takashima Seiji, Nishino Masami, Matsumura Yasushi, Takeda Hiroshi, Tanaka Toshihiro, Sato Hiroshi, Hori Masatsugu, Komuro Issei
Abstract excerpt
AIMS: We previously reported the association of single nucleotide polymorphisms in the lymphotoxin alpha (LTα) gene with susceptibility to acute myocardial infarction (AMI) and increased mortality after discharge. In the present study, we investigated whether the adverse effect of LTα C804A polymorphism on mortality could be pharmacologically modified by statin treatment after AMI. METHODS AND RESULTS: We...
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