Article
A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.
Stroke - 1 Mar 2009
Wang Xingyu, Cheng Suzanne, Brophy Victoria H, Erlich Henry A, Mannhalter Christine, Berger Klaus, Lalouschek Wolfgang, Browner Warren S, Shi Yu, Ringelstein E Bernd, Kessler Christof, Luedemann Jan, Lindpaintner Klaus, Liu Lisheng, Ridker Paul M, Zee Robert Y L, Cook Nancy R
Abstract excerpt
BACKGROUND AND PURPOSE: Ischemic stroke is a multifactorial disease with a strong genetic component. Pathways, including lipid metabolism, systemic chronic inflammation, coagulation, blood pressure regulation, and cellular adhesion, have been implicated in stroke pathophysiology, and candidate gene polymorphisms in these pathways have been proposed as genetic risk factors. METHODS: We genotyped 105 simple...
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