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Article

Lymphotoxin-alpha gene and risk of myocardial infarction in 6,928 cases and 2,712 controls in the ISIS case-control study.

PLoS genetics - 1 Jul 2006

Clarke Robert, Xu Peng, Bennett Derrick, Lewington Sarah, Zondervan Krina, Parish Sarah, Palmer Alison, Clark Sarah, Cardon Lon, Peto Richard, Lathrop Mark, Collins Rory

Abstract excerpt

Lymphotoxin-alpha (LTA) is a pro-inflammatory cytokine that plays an important role in the immune system and local inflammatory response. LTA is expressed in atherosclerotic plaques and has been implicated in the pathogenesis of atherosclerosis and coronary heart disease (CHD). Polymorphisms in the gene encoding lymphotoxin-alpha (LTA) on Chromosome 6p21 have been associated with susceptibility to CHD, but...

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Identifiers

PMID: 16839190
DOI: 10.1371/journal.pgen.0020107
PMCID: PMC1487176

Genes

LTA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Lymphotoxin-alpha gene and risk of myocardial infarction in 6,928 cases and 2,712 controls in the ISIS case-control study.PMID 16839190Read ↗

Genome-wide association study to identify single-nucleotide polymorphisms conferring risk of myocardial infarction.Semantic proximity Read ↗

Genome-wide association study to identify SNPs conferring risk of myocardial infarction and their functional analyses.Semantic proximity Read ↗

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Lymphotoxin-alpha and galectin-2 SNPs are not associated with myocardial infarction in two different German populations.Semantic proximity Read ↗

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