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Article

Functional SNPs in the lymphotoxin-alpha gene that are associated with susceptibility to myocardial infarction.

Nature genetics - 1 Dec 2002

Ozaki Kouichi, Ohnishi Yozo, Iida Aritoshi, Sekine Akihiko, Yamada Ryo, Tsunoda Tatsuhiko, Sato Hiroshi, Sato Hideyuki, Hori Masatsugu, Nakamura Yusuke, Tanaka Toshihiro

Abstract excerpt

By means of a large-scale, case-control association study using 92,788 gene-based single-nucleotide polymorphism (SNP) markers, we identified a candidate locus on chromosome 6p21 associated with susceptibility to myocardial infarction. Subsequent linkage-disequilibrium (LD) mapping and analyses of haplotype structure showed significant associations between myocardial infarction and a single 50 kb halpotype...

Topics

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Chromosomes, Human, Pair 6
Coronary Vessels
Databases, Genetic
Jurkat Cells
Lymphotoxin-alpha

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Muscle, Smooth, Vascular

Myocardial Infarction

Vascular Cell Adhesion Molecule-1

Source

Identifiers

PMID: 12426569
DOI: 10.1038/ng1047

Genes

LTA
NFKBIL1
VCAM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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