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Article

Association of lymphotoxin-alpha gene polymorphisms (rs909253, rs1800683 and rs2229094) and risk of large-artery atherosclerosis stroke in Iranian population.

The journal of gene medicine - 1 Oct 2020

Fasihi Ali, Pourhamedi Saeede, Zahedi Mohmmadsaeid, Goudarzian Maryam, Ramazi Shahin, Kafashzadeh Mehrnoosh, Heydari-Zarnagh Hafez

Abstract excerpt

BACKGROUND: Lymphotoxin-alpha (LTA), a proinflammatory cytokine, is significantly associated with the progression of atherosclerosis as an independent hazard factor for stroke. According to new genetic studies, polymorphisms in the LTA gene that influence its expression or biological function may play a role in the progress of stroke; thus, the present case-control study investigated LTA gene polymorphisms...

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PMID: 32415894
DOI: 10.1002/jgm.3229

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