Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The insulin/PI 3-kinase pathway regulates salt chemotaxis learning in Caenorhabditis elegans.

Neuron - 7 Sept 2006

Tomioka Masahiro, Adachi Takeshi, Suzuki Hiroshi, Kunitomo Hirofumi, Schafer William R, Iino Yuichi

Abstract excerpt

The insulin-like signaling pathway is known to regulate fat metabolism, dauer formation, and longevity in Caenorhabditis elegans. Here, we report that this pathway is also involved in salt chemotaxis learning, in which animals previously exposed to a chemoattractive salt under starvation conditions start to show salt avoidance behavior. Mutants of ins-1, daf-2, age-1, pdk-1, and akt-1, which encode the homologs...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3-Phosphoinositide-Dependent Protein Kinases
Share to Chemotaxis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interneurons

Share to Learning

Share to Neurons, Afferent

Share to Proto-Oncogene Proteins c-akt

Share to Receptor, Insulin

Share to Sodium Chloride

Source

Identifiers

PMID: 16950159
DOI: 10.1016/j.neuron.2006.07.024

Genes

INS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The insulin/PI 3-kinase pathway regulates salt chemotaxis learning in Caenorhabditis elegans.PMID 16950159Read ↗

Insulin-like signaling and the neural circuit for integrative behavior in C. elegans.Semantic proximity Read ↗

Aging-dependent and -independent modulation of associative learning behavior by insulin/insulin-like growth factor-1 signal in Caenorhabditis elegans.Semantic proximity Read ↗

Insulin signaling plays a dual role in Caenorhabditis elegans memory acquisition and memory retrieval.Semantic proximity Read ↗

A Gustatory Neural Circuit of Caenorhabditis elegans Generates Memory-Dependent Behaviors in Na+ Chemotaxis.Semantic proximity Read ↗

Two insulin-like peptides antagonistically regulate aversive olfactory learning in C. elegans.Semantic proximity Read ↗

Effects of sex and insulin/insulin-like growth factor-1 signaling on performance in an associative learning paradigm in Caenorhabditis elegans.Semantic proximity Read ↗

The redundancy and diversity between two novel PKC isotypes that regulate learning in Caenorhabditis elegans.Semantic proximity Read ↗

Adult single-nucleus neuronal transcriptomes of insulin signaling mutants reveal regulators of behavior and learning.Semantic proximity Read ↗

pkc-1 regulates daf-2 insulin/IGF signalling-dependent control of dauer formation in Caenorhabditis elegans.Semantic proximity Read ↗

Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor.Semantic proximity Read ↗

Neural circuit-dependent odor adaptation in C. elegans is regulated by the Ras-MAPK pathway.Semantic proximity Read ↗

Insulin/IGF-1 signaling, including class II/III PI3Ks, β-arrestin and SGK-1, is required in C. elegans to maintain pharyngeal muscle performance during starvation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.