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Article

A histone H4 lysine 20 methyltransferase couples environmental cues to sensory neuron control of developmental plasticity.

Development (Cambridge, England) - 1 Apr 2017

Delaney Colin E, Chen Albert T, Graniel Jacqueline V, Dumas Kathleen J, Hu Patrick J

Abstract excerpt

Animals change developmental fates in response to external cues. In the nematode Caenorhabditis elegans, unfavorable environmental conditions induce a state of diapause known as dauer by inhibiting the conserved DAF-2 insulin-like signaling (ILS) pathway through incompletely understood mechanisms. We have previously established a role for the C. elegans dosage compensation protein DPY-21 in the control of dauer...

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PMID: 28209779
DOI: 10.1242/dev.145722
PMCID: PMC5399626

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