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Article

Insulin-like signaling and the neural circuit for integrative behavior in C. elegans.

Genes & development - 1 Nov 2006

Kodama Eiji, Kuhara Atsushi, Mohri-Shiomi Akiko, Kimura Koutarou D, Okumura Masatoshi, Tomioka Masahiro, Iino Yuichi, Mori Ikue

Abstract excerpt

Caenorhabditis elegans exhibits a food-associated behavior that is modulated by the past cultivation temperature. Mutations in INS-1, the homolog of human insulin, caused the defect in this integrative behavior. Mutations in DAF-2/insulin receptor and AGE-1/phosphatidylinositol 3 (PI-3)-kinase partially suppressed the defect of ins-1 mutants, and a mutation in DAF-16, a forkhead-type transcriptional factor,...

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Identifiers

PMID: 17079685
DOI: 10.1101/gad.1479906
PMCID: PMC1620028

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INS

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Source receipt: pubmed, retrieved 7 Sept 2026.

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