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Article

LRP6 enhances glucose metabolism by promoting TCF7L2-dependent insulin receptor expression and IGF receptor stabilization in humans.

Cell metabolism - 5 Feb 2013

Singh Rajvir, De Aguiar Renata Belfort, Naik Sarita, Mani Sheida, Ostadsharif Kamal, Wencker Detlef, Sotoudeh Masoud, Malekzadeh Reza, Sherwin Robert S, Mani Arya

Abstract excerpt

Common genetic variations in Wnt signaling genes have been associated with metabolic syndrome and diabetes by mechanisms that are poorly understood. A rare nonconservative mutation in Wnt coreceptor LRP6 (LRP6(R611C)) has been shown to underlie autosomal dominant early onset coronary artery disease, type 2 diabetes, and metabolic syndrome. We examined the interplay between Wnt and insulin signaling pathways in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23395167
DOI: 10.1016/j.cmet.2013.01.009
PMCID: PMC3589523

Genes

LRP6

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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