Article
Rare nonconservative LRP6 mutations are associated with metabolic syndrome.
Human mutation - 1 Sept 2013
Singh Rajvir, Smith Emily, Fathzadeh Mohsen, Liu Wenzhong, Go Gwang-Woong, Subrahmanyan Lakshman, Faramarzi Saeed, McKenna William, Mani Arya
Abstract excerpt
A rare mutation in LRP6 has been shown to underlie autosomal dominant coronary artery disease (CAD) and metabolic syndrome in an Iranian kindred. The prevalence and spectrum of LRP6 mutations in the disease population of the United States is not known. Two hundred white Americans with early onset familial CAD and metabolic syndrome and 2,000 healthy Northern European controls were screened for nonconservative...
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