Unraveling the regulatory mechanisms of tetrandrine in microglial phenotypic transition and neuronal autophagy for relieving diabetic neuropathic pain.

Abstract excerpt

BACKGROUND: Diabetic neuropathic pain (DNP) is a prevalent and debilitating complication of diabetes mellitus, characterized by persistent pain and neuroinflammation. Current treatments often provide inadequate relief, highlighting the need for novel therapeutic strategies targeting its underlying mechanisms. OBJECTIVES: This study aimed to investigate the therapeutic potential of tetrandrine (Tet) in alleviating...

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