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Continuous Zebularine Treatment Effectively Sustains Demethylation in Human Bladder Cancer Cells

16 Jan 2004

Abstract excerpt

During tumorigenesis, tumor suppressor and cancer-related genes are commonly silenced by aberrant DNA methylation in their promoter regions. Recently, we reported that zebularine [1-(beta-D-ribofuranosyl)-1,2-dihydropyrimidin-2-one] acts as an inhibitor of DNA methylation and exhibits chemical stability and minimal cytotoxicity both in vitro and in vivo. Here we show that continuous application of zebularine to...

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PMID: 14729971
DOI: 10.1128/mcb.24.3.1270-1278.2004

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