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Article

NMR Characterization of Angiogenin Variants and tRNAAla Products Impacting Aberrant Protein Oligomerization.

International journal of molecular sciences - 1 Feb 2021

Fagagnini Andrea, Garavís Miguel, Gómez-Pinto Irene, Fasoli Sabrina, Gotte Giovanni, Laurents Douglas V

Abstract excerpt

Protein oligomerization is key to countless physiological processes, but also to abnormal amyloid conformations implicated in over 25 mortal human diseases. Human Angiogenin (h-ANG), a ribonuclease A family member, produces RNA fragments that regulate ribosome formation, the creation of new blood vessels and stress granule function. Too little h-ANG activity leads to abnormal protein oligomerization, resulting in...

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Identifiers

PMID: 33535464
DOI: 10.3390/ijms22031439
PMCID: PMC7867098

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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