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Article

Genome-wide landscape of liver X receptor chromatin binding and gene regulation in human macrophages

31 Jan 2012

Abstract excerpt

BACKGROUND: The liver X receptors (LXRs) are oxysterol sensing nuclear receptors with multiple effects on metabolism and immune cells. However, the complete genome-wide cistrome of LXR in cells of human origin has not yet been provided. RESULTS: We performed ChIP-seq in phorbol myristate acetate-differentiated THP-1 cells (macrophage-type) after stimulation with the potent synthetic LXR ligand T0901317 (T09)....

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PMID: 22292898
DOI: 10.1186/1471-2164-13-50

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