Article
Heat shock protein 70 gene polymorphisms in Japanese patients with aspirin-exacerbated respiratory disease.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research - 1 Apr 2013
Kikuchi Kiyokazu, Abe Shyuzo, Kodaira Kazumi, Yukawa Tatsuo, Hozawa Soichiro, Mochizuki Hiroyuki, Kurosawa Motohiro
Abstract excerpt
BACKGROUND: Aspirin-exacerbated respiratory disease (AERD) is nonatopic asthma, and the role of heat shock protein (HSP) 70 in AERD remains unknown. We analyzed HSP70 gene polymorphisms in Japanese patients with AERD. METHODS: The single-nucleotide polymorphisms in HSPA1B-179C>T and 1267A>G gene were examined in patients with AERD and those with aspirin-tolerant asthma (ATA). All patients were in a stable...
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