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Article

miR-21 mediates hematopoietic suppression in MDS by activating TGF-β signaling.

Blood - 11 Apr 2013

Bhagat Tushar D, Zhou Li, Sokol Lubomir, Kessel Rachel, Caceres Gisela, Gundabolu Krishna, Tamari Roni, Gordon Shanisha, Mantzaris Ioannis, Jodlowski Tomasz, Yu Yiting, Jing Xiaohong, Polineni Rahul, Bhatia Kavi, Pellagatti Andrea, Boultwood Jacqueline, Kambhampati Suman, Steidl Ulrich, Stein Cy, Ju Wenjun, Liu Gang, Kenny Paraic, List Alan, Bitzer Markus, Verma Amit

Abstract excerpt

Myelodysplastic syndromes (MDS) are characterized by ineffective hematopoiesis that leads to peripheral cytopenias. We observed that SMAD7, a negative regulator of transforming growth factor-beta (TGF-β) receptor-I kinase, is markedly reduced in MDS and leads to ineffective hematopoiesis by overactivation of TGF-β signaling. To determine the cause of SMAD7 reduction in MDS, we analyzed the 3'UTR of the gene and...

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Source

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Identifiers

PMID: 23390194
DOI: 10.1182/blood-2011-12-397067
PMCID: PMC3624935

Genes

SMAD7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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