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Article

miR-7977 inhibits the Hippo-YAP signaling pathway in bone marrow mesenchymal stromal cells

5 Mar 2019

Abstract excerpt

We and others have demonstrated that various abnormalities of the bone marrow (BM) mesenchymal stromal cells (MSCs) such as aberrant cytokine expression, abnormal hedgehog signaling, and impaired miRNA biogenesis are observed in patients with acute myeloid leukemia (AML). However, underlying mechanisms to induce the dysfunction of BM MSCs have not yet been clarified. We previously showed that AML cells release...

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Share to Acute Myeloid Leukemia Research
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PMID: 30835743
DOI: 10.1371/journal.pone.0213220

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