Article
RUNX1/AML1 mutant collaborates with BMI1 overexpression in the development of human and murine myelodysplastic syndromes.
Blood - 25 Apr 2013
Harada Yuka, Inoue Daichi, Ding Ye, Imagawa Jun, Doki Noriko, Matsui Hirotaka, Yahata Takashi, Matsushita Hiromichi, Ando Kiyoshi, Sashida Goro, Iwama Atsushi, Kitamura Toshio, Harada Hironori
Abstract excerpt
RUNX1/AML1 mutations have been identified in myelodysplastic syndromes (MDSs). In a mouse bone marrow transplantation model, a RUNX1 mutant, D171N, was shown to collaborate with Evi1 in the development of MDSs; however, this is rare in humans. Using enforced expression in human CD34(+) cells, we showed that the D171N mutant, the most frequent target of mutation in the RUNX1 gene, had an increased self-renewal...
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