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Article

RPL27A is a target of miR-595 and may contribute to the myelodysplastic phenotype through ribosomal dysgenesis.

Oncotarget - 26 Jul 2016

Alkhatabi Heba A, McLornan Donal P, Kulasekararaj Austin G, Malik Farooq, Seidl Thomas, Darling David, Gaken Joop, Mufti Ghulam J

Abstract excerpt

We investigated the functional consequences following deletion of a microRNA (miR) termed miR-595 which resides on chromosome 7q and is localised within one of the commonly deleted regions identified for Myelodysplasia (MDS) with monosomy 7 (-7)/isolated loss of 7q (7q-). We identified several targets for miR-595, including a large ribosomal subunit protein RPL27A. RPL27A downregulation induced p53 activation,...

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Identifiers

PMID: 27374104
DOI: 10.18632/oncotarget.10293
PMCID: PMC5216985

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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